Deceased 31 December 2008.
Orexins/hypocretins and aminergic systems
Article first published online: 27 JUN 2009
© 2009 The Authors. Journal compilation © 2009 Scandinavian Physiological Society
Special Issue: 16TH ACTA PHYSIOLOGICA INTERNATIONAL SYMPOSIUM ‘10 YEARS OF HYPOCRETINS/OREXINS-PHYSIOLOGY AND PATHOPHYSIOLOGY’
Volume 198, Issue 3, pages 263–275, March 2010
How to Cite
Eriksson, K. S., Sergeeva, O. A., Haas, H. L. and Selbach, O. (2010), Orexins/hypocretins and aminergic systems. Acta Physiologica, 198: 263–275. doi: 10.1111/j.1748-1716.2009.02015.x
- Issue published online: 28 JAN 2010
- Article first published online: 27 JUN 2009
- Received 23 April 2009, revision requested 11 May 2009, revision received 25 May 2009, accepted 4 June 2009
Orexin/hypocretin neurones in the posterior hypothalamus are mutually connected with noradrenergic, serotonergic, dopaminergic, histaminergic, and cholinergic neurone systems. They activate these targets by direct post-synaptic and indirect pre-synaptic mechanisms and in turn receive inhibitory feedback and excitatory feed forward control. With respect to behavioural state control, orexin/hypocretin neurones are conducting the orchestra of biogenic amines. This review highlights the role of these players in the control of energy administration, sleep–wake architecture, cortical activation, plasticity, and memory functions in health and disease.