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ABSTRACT

Seven cases of gastric carcinoma in Belgian shepherd dogs were histologically diagnosed at the Faculty of Veterinary Medicine of the University of Milan, in addition to the eight cases reported in 1989. In all 15 cases the lesser curvature was invaded by the tumour. Histologically, six neoplasms were signet ring cell carcinoma, five were undifferentiated carcinoma, two were mucinous adenocarcinoma and one was a tubular adenocarcinoma; one case showed different histological features (tubular and papillar adenocarcinoma, signet ring cell and undifferentiated carcinoma) none of which prevailed. The Grimelius stain showed the presence of few ente-rochromaffin cells scattered in the tumoral tissue in four cases. The examination of the pedigree of eight Belgian shepherd dogs with gastric carcinoma demonstrates that all these animals were related, suggesting a genetic mechanism in the pathogenesis of the disease.