Primary immune-mediated thrombocytopenia in a cat

Authors

  • S. Tasker,

    1. Department of Veterinary Clinical Studies, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh EH9 1QH
    Search for more papers by this author
  • A. J. Mackin,

    1. Department of Veterinary Clinical Studies, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh EH9 1QH
    Search for more papers by this author
    • 2

      College of Veterinary Medicine, Box 9825, Mississippi State University, Mississippi State, MS 39762-9825, USA

  • M. J. Day

    1. *Department of Pathology and Microbiology, Comparative Pathology Laboratory, School of Veterinary Science, Langford, Bristol BS40 5DU
    Search for more papers by this author

Abstract

A young female Somali cat was referred for investigation of chronic intermittent haematuria. Petechiae were found on the ears and ventral abdomen and further investigation revealed severe thrombocytopenia and megakaryocyte hyperplasia. Direct marrow immunohistochemistry detected anti-megakaryocyte autoantibody (immunoglobulin G), but extensive investigation failed to find secondary causes of immune-mediated thrombocytopenia, so a diagnosis of primary (autoimmune) immune-mediated thrombocytopenia was concluded. Thrombocytopenia persisted despite aggressive immunosuppressive therapy (prednisolone, azathioprine and vincristine) but resolved after oral prednisolone was replaced with dexamethasone.

Ancillary