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Combined clotrimazole irrigation and depot therapy for canine nasal aspergillosis

Authors

  • T. R. Sissener,

    1. The Queen’s Veterinary School Hospital, University of Cambridge, Madingley Road, Cambridge CB3 0ES
      *Dick White Referrals, Station Farm, London Road, Six Mile Bottom, Newmarket, Suffolk CB8 0UH
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  • N. J. Bacon,

    1. The Queen’s Veterinary School Hospital, University of Cambridge, Madingley Road, Cambridge CB3 0ES
      *Dick White Referrals, Station Farm, London Road, Six Mile Bottom, Newmarket, Suffolk CB8 0UH
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  • E. Friend,

    1. The Queen’s Veterinary School Hospital, University of Cambridge, Madingley Road, Cambridge CB3 0ES
      *Dick White Referrals, Station Farm, London Road, Six Mile Bottom, Newmarket, Suffolk CB8 0UH
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  • D. M. Anderson,

    1. The Queen’s Veterinary School Hospital, University of Cambridge, Madingley Road, Cambridge CB3 0ES
      *Dick White Referrals, Station Farm, London Road, Six Mile Bottom, Newmarket, Suffolk CB8 0UH
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  • R. A. S. White

    1. The Queen’s Veterinary School Hospital, University of Cambridge, Madingley Road, Cambridge CB3 0ES
      *Dick White Referrals, Station Farm, London Road, Six Mile Bottom, Newmarket, Suffolk CB8 0UH
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Abstract

Objectives: To evaluate the effect of short duration 1 per cent clotrimazole flush when combined with 1 per cent clotrimazole cream instilled into the frontal sinuses for the treatment of nasal aspergillosis in 14 dogs.

Methods: Fourteen dogs with clinical, radiological, serological and rhinoscopic findings consistent with nasal aspergillosis were treated by frontal sinus trephination and a short, five-minute flushing of 1 per cent topical clotrimazole solution followed by a 1 per cent clotrimazole cream instilled as a depot agent.

Results: Twelve of the 14 dogs (86 per cent) responded well to treatment and either had no clinical signs after treatment or had signs consistent with mild rhinitis during a minimum follow-up period of six months. Only one dog required multiple treatments. Treatment was well tolerated by all patients, with minimal complications.

Clinical Significance: This treatment compares favourably to previously published data using one-hour topical clotrimazole or enilconazole flushing treatment protocols. The treatment technique significantly reduced treatment time under anaesthesia.

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