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Metabolic epidermal necrosis in a dog associated with pancreatic adenocarcinoma, hyperglucagonaemia, hyperinsulinaemia and hypoaminoacidaemia

  1. T. A. Cave,
  2. H. Evans,
  3. J. Hargreaves,
  4. A. S. Blunden

Article first published online: 2 JUN 2007

DOI: 10.1111/j.1748-5827.2006.00311.x

Issue

Journal of Small Animal Practice

Journal of Small Animal Practice

Volume 48, Issue 9, pages 522–526, September 2007

Additional Information

How to Cite

Cave, T. A., Evans, H., Hargreaves, J. and Blunden, A. S. (2007), Metabolic epidermal necrosis in a dog associated with pancreatic adenocarcinoma, hyperglucagonaemia, hyperinsulinaemia and hypoaminoacidaemia. Journal of Small Animal Practice, 48: 522–526. doi: 10.1111/j.1748-5827.2006.00311.x

Author Information

  1. Cave Referrals, Sandwell, 7 Hectors Stones, Woolavington, Somerset TA7 8EG *Cambridge Specialist Laboratories, PO Box 903, Sawston, Cambridge, Cambridgeshire CB2 4ZR †Abbey Veterinary Services, 89 Queen Street, Newton Abbot, Devon TQ12 2BG ‡Animal Health Trust, Lanwades Park, Kentford, Newmarket, Suffolk CB8 7UU

Publication History

  1. Issue published online: 9 JUN 2007
  2. Article first published online: 2 JUN 2007

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A case of metabolic epidermal necrosis associated with a pancreatic carcinoma is described. Normoglycaemia, reduced serum fructosamine, and hypoaminoacidaemia were identified. Hyperinsulinaemia and hyperglucagonaemia were documented. Immunohistochemistry documented strong tumour expression of both insulin and glucagon supporting combined paraneoplastic production of both hormones by the tumour. Enteral protein and fatty acid supplementation and parenteral amino acid supplementation proved ineffective. Metastasis to regional lymph nodes was identified and the patient was euthanased.

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