Platelet distribution width and mean platelet volume in the interpretation of thrombocytopenia in dogs
Article first published online: 12 SEP 2008
© 2008 British Small Animal Veterinary Association
Journal of Small Animal Practice
Volume 49, Issue 10, pages 518–524, October 2008
How to Cite
Bommer, N. X., Shaw, D. J., Milne, E. M. and Ridyard, A. E. (2008), Platelet distribution width and mean platelet volume in the interpretation of thrombocytopenia in dogs. Journal of Small Animal Practice, 49: 518–524. doi: 10.1111/j.1748-5827.2008.00636.x
- Issue published online: 1 OCT 2008
- Article first published online: 12 SEP 2008
Objectives: To investigate the use of platelet volume indices in the interpretation of thrombocytopenia in dogs with systemic disease.
Methods: Case records of 80 control dogs and 159 thrombocytopenic dogs with systemic disease were reviewed retrospectively. The relationships between mean platelet volume, platelet distribution width and platelet count in systemically well dogs were established. Knowledge of these relationships was used to interpret thrombocytopenia in terms of the underlying disease process.
Results: There was a positive relationship between platelet distribution width and mean platelet volume. Both platelet distribution width and mean platelet volume varied in a negative relationship with platelet count, which was unaffected by signalment, underlying disease, variations in haematological parameters or serum proteins.
Clinical Significance: The interpretation of mean platelet volume and platelet distribution width in dogs requires simultaneous reference to the platelet count. Platelet volume indices did not aid interpretation of thrombocytopenia in terms of underlying pathological processes in the population studied.