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Objectives: Quality-of-life (QOL) assessment is a novel field in veterinary medicine. It shares similarities with the more established fields of human QOL assessment and animal welfare science and could prove similarly useful.

Methods: This paper draws on existing literature on human QOL assessment, animal welfare, philosophy and animal QOL assessment.

Results: It provides practical recommendations for QOL assessment in veterinary practice and in veterinary research on what should be assessed, how it should be assessed and who should assess it.

Clinical Significance: These should assist veterinarians intending to develop their use QOL assessment.