M. L. L. Mesich's current address is Louisville Veterinary Speciality and Emergency Services, 13160 Magisterial Drive, Louisville, KY 40223, USA
Gall bladder mucoceles and their association with endocrinopathies in dogs: a retrospective case-control study
Version of Record online: 1 DEC 2009
© 2009 British Small Animal Veterinary Association
Journal of Small Animal Practice
Volume 50, Issue 12, pages 630–635, December 2009
How to Cite
Mesich, M. L. L., Mayhew, P. D., Paek, M., Holt, D. E. and Brown, D. C. (2009), Gall bladder mucoceles and their association with endocrinopathies in dogs: a retrospective case-control study. Journal of Small Animal Practice, 50: 630–635. doi: 10.1111/j.1748-5827.2009.00811.x
- Issue online: 1 DEC 2009
- Version of Record online: 1 DEC 2009
- Accepted: 8 June 2009
Objective: To investigate the relationship between endocrinopathies and diagnosis of gall bladder mucocele in dogs via a retrospective case-control study.
Methods: Records of 78 dogs with a surgical or ultrasonographic diagnosis of gall bladder mucocele were examined for the presence or absence of hyperadrenocorticism, hypothyroidism and diabetes mellitus. Two age- and breed-matched controls for each gall bladder mucocele dog (156 total control dogs) were examined for the same concurrent diseases. A matched case-control analysis was performed using conditional logistic regression.
Results: The odds of mucocele in dogs with hyperadrenocorticism were 29 times that of dogs without hyperadrenocorticism (P=0·001; 95 per cent CI 3·8, 219·9). No difference was found between dogs with and without diabetes mellitus. Although a significant association was found between gall bladder mucocele and hypothyroidism, potential observation bias was also identifi ed.
Clinical Significance: Hyperadrenocorticoid dogs that were presented for acute illness with laboratory evidence of hepatobiliary disease should undergo evaluation for the presence of a biliary mucocele. Dogs diagnosed with a gall bladder mucocele should be screened for concurrent hyperadrenocorticism if clinical suspicion exists.