Hyperascorbaemia in dogs admitted to a teaching hospital intensive care unit

Authors

  • E. Groth,

    1. Comparative Internal Medicine Laboratory, College of Veterinary Medicine, University of Missouri, Columbia, MO, USA
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  • A. Honaker,

    1. Comparative Internal Medicine Laboratory, College of Veterinary Medicine, University of Missouri, Columbia, MO, USA
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    • Honaker's current address is Division of Marine Biology and Fisheries, Rosenstiel School of Marine and Atmospheric Science, University of Miami, FL, USA

  • K. Osterbur,

    1. Comparative Internal Medicine Laboratory, College of Veterinary Medicine, University of Missouri, Columbia, MO, USA
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  • S. J. Deitschel,

    1. Comparative Internal Medicine Laboratory, College of Veterinary Medicine, University of Missouri, Columbia, MO, USA
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    • S. J. Deitschel's current address is Pittsburgh Veterinary Specialty and Emergency Center, 807 Camp Horne Road, Pittsburgh, PA 15237, USA

  • A. O. Odunayo,

    1. Comparative Internal Medicine Laboratory, College of Veterinary Medicine, University of Missouri, Columbia, MO, USA
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    • O. Odunayo's current address is Auburn University College of Veterinary Medicine, 612 Hoerlein Hall, Auburn, AL 36849, USA

  • C.-H. Chang,

    1. Comparative Internal Medicine Laboratory, College of Veterinary Medicine, University of Missouri, Columbia, MO, USA
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  • A. DeClue

    1. Comparative Internal Medicine Laboratory, College of Veterinary Medicine, University of Missouri, Columbia, MO, USA
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Abstract

Objective

To determine whether or not dogs develop a deficiency of ascorbic acid during hospitalisation in an intensive care unit.

Methods

Blood samples were collected daily for up to three days from dogs hospitalised in an intensive care unit for 36 to 72 hours (n = 16) or ê72 hours (n = 20) and from healthy dogs (n = 13). Plasma total ascorbic acid concentrations were measured using a colorimetric method involving a reaction between ascorbic acid, 2,6 dichlorophenol-indophenol, thiourea and dinitrophenyl hydrazine. Additionally, clinical data were recorded for each patient.

Results

Dogs hospitalised for ê72 hours had significantly greater plasma ascorbic acid concentrations on day 3 compared to days 1 and 2. There was no difference in plasma ascorbic acid concentrations between days 1 and 2 for dogs hospitalised for 36 to 72 hours. Plasma ascorbic acid concentrations were significantly greater for each day of sampling for the hospitalised dogs compared to the control dogs.

Clinical Significance

Plasma ascorbic acid concentrations appear to increase during hospitalisation, and supplementation may not be indicated in dogs hospitalised in an intensive care unit.

Ancillary