PAPER
You have free access to this content
Clinical efficacy and safety of a water-soluble micellar paclitaxel (Paccal Vet) in canine mastocytomas
Article first published online: 27 NOV 2012
DOI: 10.1111/j.1748-5827.2012.01304.x
© 2012 British Small Animal Veterinary Association
Additional Information
How to Cite
Rivera, P., Åkerlund-Denneberg, N., Bergvall, K., Kessler, M., Rowe, A., Willmann, M., Persson, G., Kastengren Fröberg, G., Westberg, S. and von Euler, H. (2013), Clinical efficacy and safety of a water-soluble micellar paclitaxel (Paccal Vet) in canine mastocytomas. Journal of Small Animal Practice, 54: 20–27. doi: 10.1111/j.1748-5827.2012.01304.x
Publication History
- Issue published online: 26 DEC 2012
- Article first published online: 27 NOV 2012
References
- VCOG-CTCAE (2004) Veterinary Co-operative Oncology Group - Common Terminology Criteria for Adverse Events (VCOG-CTCAE) following chemotherapy or biological antineoplastic therapy in dogs and cats v1.0. Veterinary and Comparative Oncology 2, 195-213
- , , , , , & (2009) Concurrent carboplatin/paclitaxel and intravaginal radiation in surgical stage I-II serous endometrial cancer. Gynecologic Oncology 112, 142-145
- , , , & (2004) Vinblastine and prednisolone as adjunctive therapy for canine cutaneous mast cell tumors. Journal of the American Animal Hospital Association 40, 124-130
- , , , , , , , , & (2009) Phase 1/2 study of intravenous paclitaxel and oral cyclophosphamide in pretreated metastatic urothelial bladder cancer patients. Cancer 115, 517-523
- & (2007) Advances in the diagnosis and management of cutaneous mast cell tumours in dogs. Journal of Small Animal Practice 48, 424-431
- , , , & (1968) Survey of animal neoplasms in Alameda and Contra Costa Counties. California. II. Cancer morbidity in dogs and cats from Alameda County. Journal of the National Cancer Institute 40, 307-318
- (1994) Review of phase II trials of Taxol (paclitaxel) in patients with advanced ovarian cancer. Annals of Oncology : Official Journal of the European Society for Medical Oncology/ESMO 5(Suppl 6), S29-32
- , , , , , , & (1991) A phase II study of taxol in patients with malignant melanoma. Investigation of New Drugs 9, 59-64
- , , , , & (2006) Evaluation of a two-centimeter lateral surgical margin for excision of grade I and grade II cutaneous mast cell tumors in dogs. Journal of the American Veterinary Medical Association 228, 210-215
- , , , , , & (1995) Phase II study with paclitaxel for the treatment of advanced inoperable non-small cell lung cancer. Lung Cancer 12(Suppl 2), S101-106
- , , & (1998) Multi-agent chemotherapy for mast cell tumours in the dog. Veterinary Quarterly 20, 28-31
- , , , , , , & (2008) A phase II clinical trial of vinorelbine in dogs with cutaneous mast cell tumors. Journal of Veterinary Internal Medicine 22, 388-393
- (2001) General and recent aspects of the chemistry and structure-activity relationships of taxoids. Current Pharmaceutical Design 7, 1229-1249
- , , , , , , , , , , , & (2008) Masitinib is safe and effective for the treatment of canine mast cell tumors. Journal of Veterinary Internal Medicine 22, 1301-1309
- , , , , , , , , & (2005) Cytotoxic activity of a new paclitaxel formulation, Pacliex, in vitro and in vivo. Cancer Chemotherapy and Pharmacology 55, 47-54
- , , , , & (2011) Outcomes of dogs with grade 3 mast cell tumors: 43 cases (1997-2007). Journal of the American Animal Hospital Association 47, 37-44
- , , , & (2004) Detection of c-kit mutations in canine mast cell tumors using fluorescent polyacrylamide gel electrophoresis. Journal of Veterinary Diagnostic Investigation 16, 95-100
- (2002) Mechanism of action of antitumor drugs that interact with microtubules and tubulin. Current Medicinal Chemistry. Anti-cancer Agents 2, 1-17
- & (2003) Mast cell tumors in the dog. The Veterinary Clinics of North America. Small Animal Practice 33, 473-489, v
- , , , , , , , , , , , , & (2009) Multi-center, placebo-controlled, double-blind, randomized study of oral toceranib phosphate (SU11654), a receptor tyrosine kinase inhibitor, for the treatment of dogs with recurrent (either local or distant) mast cell tumor following surgical excision. Clinical Cancer Research 15, 3856-3865
- , , , , & (2007) Paclitaxel: a review of adverse toxicities and novel delivery strategies. Expert Opinion on Drug Safety 6, 609-621
- , , , , , , & (1994) Response of canine mast cell tumors to treatment with oral prednisone. Journal of Veterinary Internal Medicine 8, 406-408
- , , , , , , & (1997) Vincristine therapy for mast cell tumors in dogs. Journal of Veterinary Internal Medicine 11, 375-378
- (2003) Mast cell tumours. In: BSAVA Manual of Canine and Feline Oncology. 2nd edn. Eds J. Dobson and B. D. X. Lascelles. BSAVA, Glouchester. pp 161-167
- (1980) TNM classification of tumours in domestic animals. In: TNM Classification of Tumours in Domestic Animals. 1st edn. Ed L. N. Owen. World Health Organization, Geneva, Switzerland
- , , , , , & (2004) Antiangiogenic activity of paclitaxel is associated with its cytostatic effect, mediated by the initiation but not completion of a mitochondrial apoptotic signaling pathway. Molecular Cancer Therapy 3, 1301-1310
- , & (1984) Canine cutaneous mast cell tumor: morphologic grading and survival time in 83 dogs. Veterinary Pathology 21, 469-474
- , & (2007) Angiosarcomas and taxanes. Current Treatment Options in Oncology 8, 428-434
- (1969) Canine mastocytoma: excess risk as related to ancestry. Journal of the National Cancer Institute 42, 435-443
- , , , , , , & (2004) Efficacy and toxicity of paclitaxel (Taxol) for the treatment of canine malignant tumors. Journal of Veterinary Internal Medicine 18, 219-222
- , , , , , & (1999) Treatment of canine mast cell tumors with CCNU (lomustine). Journal of Veterinary Internal Medicine 13, 601-605
- , & (2010) Efficacy of maropitant in the prevention of delayed vomiting associated with administration of doxorubicin to dogs. Journal of Veterinary Internal Medicine 24, 1452-1457
- , , , & (2007) Mitotic index is predictive for survival for canine cutaneous mast cell tumors. Veterinary Pathology 44, 335-341
- , , , & (1993) Clinical toxicities encountered with paclitaxel (Taxol). Seminars in Oncology 20, 1-15
- , , & (1995) A phase II trial of paclitaxel (Taxol) as first line treatment in advanced breast cancer. Investigation of New Drugs 13, 217-222
- , , & (2009) Chlorambucil and prednisolone chemotherapy for dogs with inoperable mast cell tumours: 21 cases. Journal of Small Animal Practice 50, 284-289
- , & (2006) Outcome and prognostic factors following adjuvant prednisone/vinblastine chemotherapy for high-risk canine mast cell tumour: 61 cases. Journal of Veterinary Medical Sciences 68, 581-587
- (1987) Performance status score. In: Veterinary Cancer Medicine. 2nd edn. Eds G. H. Theilen and B. R. Madewell. Lea and Febiger, Philadelphia, PA. USA. p 59
- , , , , , , , , , & (2000) New guidelines to evaluate the response to treatment in solid tumors. Journal of the National Cancer Institute 92, 205-216
- (2009) Supporting the veterinary cancer patient on chemotherapy: neutropenia and gastrointestinal toxicity. Topics in Companion Animal Medicine 24, 122-129
- , , , , , , , , , , , , , , , , , , , , , , & (2012) A randomized trial investigating the efficacy and safety of water soluble micellar paclitaxel (Paccal Vet) for treatment of nonresectable grade 2 or 3 mast cell tumors in dogs. Journal of Veterinary Internal Medicine 26, 598-607
- , & (2007) Impact of chemotherapeutic dose intensity and hematologic toxicity on first remission duration in dogs with lymphoma treated with a chemoradiotherapy protocol. Journal of Veterinary Internal Medicine 21, 1332-1339
- , , , & (2012) A dose-finding study with a novel water-soluble formulation of paclitaxel for the treatment of malignant high-grade solid tumours in dogs. Veterinary and Comparative Oncology [E-Pub ahead of print, Mar 9]
- , & (2004) Use of kit internal tandem duplications to establish mast cell tumor clonality in 2 dogs. Journal of Veterinary Internal Medicine 18, 915-917

1748-5827/asset/JSAP_left.gif?v=1&s=1230053d6e2962fa35f93ffb0ee07e5141755e6d)
1748-5827/asset/JSAP_right.gif?v=1&s=4a52cc4d45cba4212e11fad24d9b072b7cf8348a)
