The development of nanotechnology intensifies challenges to the traditional understanding of how to pursue scientific and technological knowledge. Science can no longer be construed simply as the ideal of the quest for truth (i.e., “pure science”). Science has become the source of economic power and political power. In this paper, I argue that nanotechnology is a cardinal exemplar of “this politicization.” At the same time, I assert that this new scientific ethos offers the possibility of a better integration of ethical and philosophical reflections at the core of scientific and technological development.