Conflicts among Multinational Ethical and Scientific Standards for Clinical Trials of Therapeutic Interventions

Authors

  • Jacob M. Kolman,

    1. Research assistant at the Baylor College of Medicine Center for Medical Ethics and Health Policy, Houston Texas.
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  • Nelda P. Wray,

    1. Research scientist in the Department of Surgery at the Methodist Hospital in Houston, Texas, and a Research Professor of Medicine in Surgery at Weill Cornell Medical College, the academic affiliate of The Methodist Hospital.
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  • Carol M. Ashton,

    1. Research scientist in the Department of Surgery at the Methodist Hospital in Houston, Texas, and a Research Professor of Medicine in Surgery at Weill Cornell Medical College, the academic affiliate of The Methodist Hospital.
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  • Danielle M. Wenner,

    1. Cleveland Fellow in Advanced Bioethics at the Cleveland Clinic.
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  • Anna F. Jarman,

    1. Research assistant at the Methodist Hospital Research Institute, Department of Surgery.
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  • Baruch A. Brody

    1. Leon Jaworski Professor of Biomedical Ethics at Baylor College of Medicine and the Andrew Mellon Professor of Humanities in the Department of Philosophy at Rice University.
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Abstract

Utilizing a sorted compendium of international clinical trial standards, investigators identified 15 conflicts among ethical and methodological guidance. Analysis distinguishes interpretational issues, lack of clarity, and contradiction as factors to be addressed if international trial guidance is to be improved.

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