IRB Decision-Making with Imperfect Knowledge: A Framework for Evidence-Based Research Ethics Review
Version of Record online: 3 JAN 2013
© 2012 American Society of Law, Medicine & Ethics, Inc.
The Journal of Law, Medicine & Ethics
Special Issue: SYMPOSIUM 1: Nanodiagnostics and Nanotherapeutics: Building Research Ethics and Oversight
Volume 40, Issue 4, pages 951–969, Winter 2012
How to Cite
Anderson, E. E. and DuBois, J. M. (2012), IRB Decision-Making with Imperfect Knowledge: A Framework for Evidence-Based Research Ethics Review. The Journal of Law, Medicine & Ethics, 40: 951–969. doi: 10.1111/j.1748-720X.2012.00724.x
- Issue online: 3 JAN 2013
- Version of Record online: 3 JAN 2013
Here we describe the five steps of evidence-based practice as applied to research ethics review and apply these steps to three exemplar dilemmas: incentive payments in substance abuse research; informed consent for biobanking; and placebo-controlled trials involving pregnant women in order to demonstrate the potential of empirical data to inform and improve IRB decision-making.