This article introduces the special issue of Human Resource Management Journal on International Human Resource Management in the 21st Century. We begin by considering some of the key aspects of the changing landscape of international business and the key emergent issues for IHRM at the beginning of the 21st century. Key themes which we consider include: the changing nature of the global economic landscape, with a particular focus on India, China and Central and Eastern Europe; increasing global terrorism in the post-9/11 world; the changing nature of careers; and, finally, changing patterns of global staffing. We then conclude by outlining the content of the special issue.