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Montelukast in allergic rhinitis: a systematic review and meta-analysis


J. Grainger, Department of Otorhinolaryngology, University Hospital Birmingham, Queen Elizabeth Hospital, Edgbaston, Birmingham, UK, Tel.: +44 121 772 1311; fax: +44 121 627 2291; e-mail:

Key points

• Allergic rhinitis is common.

• This systematic review outlines the evidence regarding montelukast in allergic rhinitis and provides a meta-analysis of its efficacy.

• The evidence suggests that montelukast does reduce nasal symptom score by 3.4% (95% CI: 2.5% to 4.2%) when compared with placebo.

• Montelukast is not as effective as topical nasal steroids or antihistamines and should therefore be regarded as second line therapy.

• When used, montelukast should be used in combination with an antihistamine.