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Zebrafish as a Model System for Studying Neuronal Circuits and Behaviora

Authors

  • JOSEPH R. FETCHO,

    Corresponding author
    1. Department of Neurobiology and Behavior, Life Science Building, State University of New York at Stony Brook, Stony Brook, New York 11794-5230, USA
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  • KATHARINE S. LIU

    1. Department of Neurobiology and Behavior, Life Science Building, State University of New York at Stony Brook, Stony Brook, New York 11794-5230, USA
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  • a

    This work was supported by NIH grant NS26539 (J.R.F.) and a postdoctoral fellowship from the Helen Hay Whitney Foundation (K.S.L.).

Corresponding author; e-mail: JFetcho@neurobio.sunysb.edu

Abstract

Abstract: Zebrafish are best known as a model system for studies of the genetics of development. They do, however, also offer many advantages for the study of neuronal circuitry because the larvae are transparent, allowing optical studies of neuronal activity and noninvasive photoablations of individual neurons. The combination of these optical methods with genetics through the use of mutant and transgenic lines of fish should make the zebrafish model a unique and powerful one among vertebrates. Here we review the strengths of the model and the possibilities it offers for studies of the neural basis of behavior.

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