This work was supported by IX Progetto AIDS (Grant 9403-30) and Progetto Terapia Antivirale/AIDS (Grant 880-12) Istitulo Superiore di Sanità Roma, CNR Grant 93.00466.PF40.01415, Regione Lombardia Grant No. 1378, Italy; and National Institutes of Health Grant NS10046 from the National Institute of Neurological Diseases and Stroke.
The Neuropeptide α-MSH in HIV Infection and Other Disorders in Humansa
Article first published online: 7 FEB 2006
Annals of the New York Academy of Sciences
Volume 840, NEUROIMMUNOMODULATION: MOLECULAR ASPECTS, INTEGRATIVE SYSTEMS, AND CLINICAL ADVANCES pages 848–856, May 1998
How to Cite
CATANIA, A., AIRAGHI, L., GAROFALO, L., CUTULI, M. and LIPTON, J. M. (1998), The Neuropeptide α-MSH in HIV Infection and Other Disorders in Humans. Annals of the New York Academy of Sciences, 840: 848–856. doi: 10.1111/j.1749-6632.1998.tb09622.x
- Issue published online: 7 FEB 2006
- Article first published online: 7 FEB 2006
Abstract: We measured plasma concentration of α-melanoctye-stimulating hormone (α-MSH), a proopiomelanocortin derivative that modulates pyrogenic and proinflammatory effects of cytokines, in infectious and inflammatory disorders in humans to learn if changes in this peptide take place in naturally occurring disease. α-MSH was elevated in HIV-infected patients of the CDC groups III and IV. Although the peptide increased in the circulation of normal subjects injected with endotoxin, it was reduced in patients with septic syndrome. α-MSH was found in the synovial fluid of arthritis patients, and its concentration was greater in the forms of arthritis marked by greater inflammation. We found that α-MSH is increased in the circulation of patients with acute myocardial infarction receiving thrombolitic therapy. Plasma concentrations of α-MSH is increased in the circulation of patients with acute myocardial infarction receiving thrombolitic therapy. Plasma concentrations of α-MSH were lower in healthy elderly subjects than in young controls. Because an excess of proinflammatory cytokines can have detrimental effects, we investigated the influences of α-MSH on the production of interleukin-1 (IL-1) and tumor necrosis factor (TNF) in HIV-infected patients and in patients with septic syndrome. Production of these cytokines in whole-blood samples stimulated with endotoxin was significantly reduced by treatment of blood with α-MSH. α-MSH has been injected into at least 106 human subjects to study its effects on pituitary function, menstrual bleeding, and tanning. The peptide was always well tolerated. α-MSH administration could open new perspectives in treatment of inflammatory diseases in humans.