5-HT4 Receptors: Cloning and Expression of New Splice Variants

  1. S. CLAEYSEN1,
  2. P. FAYE2,
  3. M. SEBBEN1,
  4. S. TAVIAUX3,
  5. J. BOCKAERT1,
  6. A. DUMUIS1,*

Article first published online: 7 FEB 2006

DOI: 10.1111/j.1749-6632.1998.tb10172.x

Issue

Annals of the New York Academy of Sciences

Additional Information

How to Cite

CLAEYSEN, S., FAYE, P., SEBBEN, M., TAVIAUX, S., BOCKAERT, J. and DUMUIS, A. (1998), 5-HT4 Receptors: Cloning and Expression of New Splice Variants. Annals of the New York Academy of Sciences, 861: 49–56. doi: 10.1111/j.1749-6632.1998.tb10172.x

Author Information

  1. 1

    CNRS UPR 9023, Centre CNRS-INSERM de Pharmacologie-Endocrinologie (CCIPE), 141 rue de la Cardonille, 34094 Montpellier cedex 5, France

  2. 2

    Laboratoires Fournier (S.C.A.), 50 Rue de Dijon, 21121 Daix cedex 05, France

  3. 3

    CRBM - CNRS, 1919 route de Mende, 34293 Montpellier cedex 5, France

* Corresponding author: Tel: +33.4.67.14.29.34; Fax: +33.4.67.54.24.32; http://dumuis@ccipe.montp.inserm.fr

Publication History

  1. Issue published online: 7 FEB 2006
  2. Article first published online: 7 FEB 2006

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ABSTRACT: On the basis of differences in the potencies and intrinsic activity of 5-HT4 receptor agonists in different biological models it has been suggested that there is heterogeneity among 5-HT4 receptors. Here, we report the molecular cloning of several 5-HT4 receptor splice variants in mouse, rat, and human brain. Our data suggest that the differences in efficacy of 5-HT4 ligands on 5-HT4 receptor-mediated responses in several tissues is due to differences in coupling efficiency rather than to the presence of different 5-HT4 receptor isoforms.

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