Supported, in part, by the Medical Research Council of Canada, the Fonds de la recherche en santé du Québec and the Royal Victoria Hospital Research Institute.
Role of Somatodendritic 5-HT Autoreceptors in Modulating 5-HT Neurotransmissiona
Article first published online: 7 FEB 2006
Annals of the New York Academy of Sciences
Volume 861, ADVANCES IN SEROTONIN RECEPTOR RESEARCH: MOLECULAR BIOLOGY, SIGNAL TRANSDUCTION, AND THERAPEUTICSa pages 204–216, December 1998
How to Cite
BLIER, P., PIÑEYRO, G., EL MANSARI, M., BERGERON, R. and DE MONTIGNY, C. (1998), Role of Somatodendritic 5-HT Autoreceptors in Modulating 5-HT Neurotransmission. Annals of the New York Academy of Sciences, 861: 204–216. doi: 10.1111/j.1749-6632.1998.tb10192.x
- Issue published online: 7 FEB 2006
- Article first published online: 7 FEB 2006
ABSTRACT: A very important element controlling serotonin (5-HT) release throughout the brain is the 5-HT1A autoreceptor present on the soma and dendrites of 5-HT neurons since it exerts a negative feedback influence on their firing activity. This 5-HT1A autoreceptor receives an increased activation by endogenous 5-HT at the beginning of a treatment with a selective 5-HT reuptake inhibitor (SSRI) and, consequently, a decreased 5-HT neuronal firing activity is obtained. As the SSRI treatment is prolonged, the 5-HT1A autoreceptor desensitizes and firing activity is restored in the presence of the SSRI. That this adaptive change underlies, at least in part, the delayed therapeutic effect of SSRI in major depression is supported by the acceleration of the antidepressant response by the concomitant administration of the 5-HT1A autoreceptor antagonist pindolol with SSRIs.