Clinical Islet Transplantation: A Review

Authors

  • JOSÉ OBERHOLZER,

    Corresponding author
    1. Division of Surgical Research, Department of Surgery, University Hospital, Rue Micheli-du-Crest 24, 1211 Geneva 14, Switzerland.
    • Corresponding author: Division of Surgical Research, Department of Surgery, University Hospital, Rue Micheli-du-Crest 24, 1211 Genève 14, Switzerland; (41) 22 372 33 11 (voice); (41) 22 372 77 55 (fax); celtrans@cmu.unige.ch (e-mail)

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  • FRÉDÉRIC TRIPONEZ,

    1. Division of Surgical Research, Department of Surgery, University Hospital, Rue Micheli-du-Crest 24, 1211 Geneva 14, Switzerland.
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  • JINNING LOU,

    1. Division of Surgical Research, Department of Surgery, University Hospital, Rue Micheli-du-Crest 24, 1211 Geneva 14, Switzerland.
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  • PHILIPPE MOREL

    1. Division of Surgical Research, Department of Surgery, University Hospital, Rue Micheli-du-Crest 24, 1211 Geneva 14, Switzerland.
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Abstract

ABSTRACT: For decades, the inability of insulin therapy to physiologically control glycemia in type I diabetic patients has motivated the search for insulin-delivering grafts. Islet autotransplantation is such a therapeutic approach to prevent diabetes mellitus following a major pancreatectomy, whereas allo-transplantation is generally prescribed for type I diabetic patients with a functional solid organ graft, or for patients awaiting one. As of today, over 150 patients have been autotransplanted world-wide, following total or subtotal pancreatectomy, permitting an insulin-independence in nearly 40% of patients. Furthermore, more than 350 islet allotransplantations have been performed. Recent results show improved metabolic control in over 50% of cases and insulin-independence in approximately 20%. This chapter presents a literature review including preliminary human islet transplantation data from the University of Geneva.

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