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Keywords:

  • AD susceptibility genes;
  • Amyloid-beta hypothesis;
  • Tau protein mutations;
  • APOE;
  • Inheritance of AD;
  • Familial AD

Abstract: At least four different genes have been identified that are associated with inherited susceptibility to Alzheimer's disease. Some of the genes are highly penetrant (PS1, PS2, bAPP); the other, APOE, is a weaker susceptibility factor. Several additional genes are suspected to exist but have not yet been cloned.