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Keywords:

  • Neurodegeneration;
  • Cell death;
  • Alzheimer'sdisease;
  • Apoptosis;
  • Neurites;
  • Amyloid

Abstract: We hypothesize that insults in the local microenvironment may cause selective, local neurite degeneration by apoptotic-like mechanisms, leading to the loss of synaptic connectivity observed in the Alzheimer disease brain. This may be an early mechanism of neurodegeneration, potentially contributing to neuronal vulnerability and disease pathogenesis.