Cellular Mechanisms of Calcium and Vitamin D in the Inhibition of Colorectal Carcinogenesis

Authors

  • SERGIO A. LAMPRECHT,

    1. Strang Cancer Prevention Center, New York, New York 10021, USA
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  • MARTIN LIPKIN

    Corresponding author
    1. Strang Cancer Prevention Center, New York, New York 10021, USA
    • Address for correspondence: Dr. M. Lipkin, Strang Cancer Research Laboratory at the Rockefeller University, 1230 York Avenue, New York, NY 10021.

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Abstract

Convincing evidence is available showing that dietary calcium and vitamin D impede the development of colonic carcinogenesis. The major cellular modes of action of calcium and vitamin D which can contribute to the inhibition of colonic neoplasia are reviewed in this article. These consist of complex series of signaling events induced by the chemopreventive agents acting at various tiers of colonic cell organization.

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