Dendritic Cell Development from Common Myeloid Progenitors


Address for correspondence: Markus G. Manz, Department of Pathology and Developmental Biology, B261 Beckman Center, Stanford University School of Medicine, 279 Campus Drive, Stanford, California 94305-5428. e-mail: Voice: 650-725-5808; fax: 650-498-6255.


Abstract: Dendritic cells (DCs) are professional antigen-presenting cells which both initiate adaptive immune responses and control tolerance to self-antigens. It has been suggested that these different effects on responder cells depend on subsets of DCs arising from either myeloid or lymphoid hematopoietic origins. In this model, CD8α+ Mac-1 DCs are supposed to be of lymphoid while CD8α Mac-1+ DCs are supposed to be of myeloid origin. Here we summarize our findings that both CD8α+ and CD8α DCs can arise from clonogenic common myeloid progenitors (CMPs) in both thymus and spleen. Therefore CD8a expression on DCs does not indicate a lymphoid origin and differences among CD8α+ and CD8α DCs might rather reflect maturation status than ontogeny. On the basis of transplantation studies, it seems likely that most of the DCs in secondary lymphoid organs and a substantial fraction of thymic DCs are myeloid-derived.