From Castration-Induced Apoptosis of Prostatic Epithelium to the Use of Apoptotic Genes in the Treatment of Prostate Cancer


Address for correspondence: Marco Marcelli, M.D., Department of Medicine, Baylor College of Medicine and VA Medical Center, 2002 Holcombe Blvd., Houston, Texas 77030. Voice: 713 794 7945; fax: 713 794 7771;


Abstract: Current knowledge of the mechanisms regulating androgen-ablation-induced apoptosis is reviewed, and our efforts to develop a system in which genes of the apoptotic pathway are used to induce therapeutic apoptosis in experimental models of prostate cancer are described.