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Keywords:

  • mesenchymal stem cells;
  • stromal cells;
  • stem cell transplantation;
  • hematopoietic stem cells;
  • engraftment

Abstract: Techniques have recently beome available to isolate and grow mesenchymal progenitors and to manipulate their growth under defined in vitro culture conditions. As a result mesenchymal stem cells can be rapidly expanded to numbers that are required for clinical application. This has allowed the clinical testing of culture-expanded MSCs in the context of hematopoietic stem cell transplantation. In this paper we discuss the role of MSCs in hematopoietic engraftment after transplantation.