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α1-Adrenergic Activation Upregulates Expression of Relaxin Receptor RXFP1 in Cardiomyocytes


Address for correspondence: Xiao-Lei Moore, Baker Heart Research Institute, P.O. Box 6492, St. Kilda Road Central, Melbourne, Victoria 8008, Australia. Voice: +613-85321297; fax: +613-85321100.


Cardiac RXFP1 was upregulated upon activation of the α1-adrenergic receptor (AR) through signal pathways involving protein kinase A and C and ERK. In contrast, β1-AR activation downregulated expression of cardiac RXFP1 and it further counteracted the α1-AR-mediated RXFP1 upregulation.