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Relaxin in Endometriosis

Authors

  • Sara S. Morelli,

    1. Department of Obstetrics, Gynecology and Women's Health, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey, 07103, USA
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  • Felice Petraglia,

    1. Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy
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  • Gerson Weiss,

    1. Department of Obstetrics, Gynecology and Women's Health, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey, 07103, USA
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  • Stefano Luisi,

    1. Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy
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  • Pasquale Florio,

    1. Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy
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  • Laura T. Goldsmith

    1. Department of Obstetrics, Gynecology and Women's Health, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey, 07103, USA
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Address for correspondence: Sara S. Morelli, M.D., Department of Obstetrics, Gynecology and Women's Health, New Jersey Medical School of UMDNJ, 185 South Orange Avenue, MSB E506, Newark, NJ 07103. Voice: +973-972-5136; fax: +973-972-4574. morellsa@umdnj.edu

Abstract

Endometriosis is an important contributing factor to chronic pelvic pain and infertility. Matrix metalloproteinases (MMPs) and vascular endothelial growth factor (VEGF) have each been implicated in the establishment of endometriotic lesions. Since relaxin regulates the expression of MMPs and VEGF in the endometrium, we tested the hypothesis that relaxin plays a role in endometriosis by comparing the expression of relaxin mRNA and its LGR7 (RXFP1) receptor mRNA in normal human endometrium to those in samples from patients with endometriosis.

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