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Relaxin-Induced Changes in Renal Function and RXFP1 Receptor Expression in the Female Rat

Authors


Address for correspondence: Dr. Nick Ashton, Faculty of Life Sciences, University of Manchester, 1.124 Stopford Building, Oxford Road, Manchester M13 9PT, UK. Voice: +44 (0)161 275 5454; fax: +44 (0) 161 275 3938. nick.ashton@manchester.ac.uk

Abstract

Relaxin causes renal hyperfiltration, natriuresis, and diuresis in male rats. This study determined the effect of recombinant human relaxin (rhRLX) on renal function in the female rat. After 7 days of rhRLX treatment (0.4 μg/h) urinary excretion of sodium and chloride were significantly lower in the rhRLX-treated group, but urine flow rate was not different from that in controls. Quantitative PCR showed that the RXFP1 receptor was expressed in both the renal cortex and medulla; immuno-localization revealed expression in the proximal tubule and inner medullary collecting ducts. These data show that relaxin elicits pregnancy-like changes in renal function in the female rat.

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