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Neuronal Cell Survival

The Role of Interleukins

Authors

  • Elizabeth Giestal De Araujo,

    1. Departamento de Neurobiologia, Programa de Neuroimunologia, Instituto de Biologia, Universidade Federal Fluminense, Niterói, Rio de Janeiro, Brazil
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  • Gustavo Mataruna Da Silva,

    1. Departamento de Neurobiologia, Programa de Neuroimunologia, Instituto de Biologia, Universidade Federal Fluminense, Niterói, Rio de Janeiro, Brazil
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  • Aline Araujo Dos Santos

    1. Departamento de Neurobiologia, Programa de Neuroimunologia, Instituto de Biologia, Universidade Federal Fluminense, Niterói, Rio de Janeiro, Brazil
    2. Departamento de Fisiologia e Farmacologia, Instituto Biomédico, Universidade Federal Fluminense, Niterói, Rio de Janeiro, Brazil
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Address for correspondence: Elizabeth Giestal de Araujo, Departamento de Neurobiologia, Programa de Neuroimunologia, Instituto de Biologia, Universidade Federal Fluminense, Caixa Postal 100180, Niterói – RJ, Brazil. CEP: 24001-970. Voice: 55 21 26292276; fax: 26292268. egiestal@vm.uff.br

Abstract

One of the central issues in neuroscience today is the study of the mechanisms of neuronal survival. Since the discovery of nerve growth factor (almost 60 years ago), many groups have clearly demonstrated the central role of neurotrophins on the regulation of neuronal cell survival during developmental stages as well as during adult life. However, neurotrophins are not alone in regulating neuronal survival, and many groups have demonstrated the effect of different cytokines on this phenomenon. In this brief review we will address the effect of interleukins (IL), particularly IL-2, IL-6, and IL-4, on the survival of neuronal cells.

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