These authors contributed equally to this work.
Neuropilins, Semaphorins, and Their Role in Thymocyte Development
Article first published online: 9 FEB 2009
© 2009 New York Academy of Sciences
Annals of the New York Academy of Sciences
Volume 1153, Neuroimmunomodulation: From Fundamental Biology to Therapy pages 20–28, February 2009
How to Cite
Mendes-da-Cruz, D. A., Lepelletier, Y., Brignier, A. C., Smaniotto, S., Renand, A., Milpied, P., Dardenne, M., Hermine, O. and Savino, W. (2009), Neuropilins, Semaphorins, and Their Role in Thymocyte Development. Annals of the New York Academy of Sciences, 1153: 20–28. doi: 10.1111/j.1749-6632.2008.03980.x
- Issue published online: 9 FEB 2009
- Article first published online: 9 FEB 2009
- thymocyte migration;
- thymocyte development
Some molecules described in the nervous system are also expressed in cells involved in the control of the immune response, suggesting they have a role as common mechanisms between neuroendocrine and immune systems. In this review, we focus on the expression and role of neuropilins (NPs) and their soluble ligands class 3 semaphorins in thymus physiology, particularly migration of developing thymocytes. We also discuss the concept of multivectorial thymocyte migration, including semaphorins, as a new individual cell migration vector.