Neuropilins, Semaphorins, and Their Role in Thymocyte Development

Authors

  • Daniella Arêas Mendes-da-Cruz,

    1. Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil
    2. Paris Descartes University, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8147, Necker Hospital, Paris, France
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  • Yves Lepelletier,

    1. Paris Descartes University, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8147, Necker Hospital, Paris, France
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  • Anne C. Brignier,

    1. Paris Descartes University, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8147, Necker Hospital, Paris, France
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  • Salete Smaniotto,

    1. Institute of Biomedical and Health Sciences, Federal University of Alagoas, Maceió, Brazil
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  • Amédée Renand,

    1. Paris Descartes University, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8147, Necker Hospital, Paris, France
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  • Pierre Milpied,

    1. Paris Descartes University, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8147, Necker Hospital, Paris, France
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  • Mireille Dardenne,

    1. Paris Descartes University, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8147, Necker Hospital, Paris, France
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  • Olivier Hermine,

    1. Paris Descartes University, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8147, Necker Hospital, Paris, France
    2. Assistance Publique, Hôpitaux de Paris, Paris, France
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    • These authors contributed equally to this work.

  • Wilson Savino

    1. Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil
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    • These authors contributed equally to this work.


Address for correspondence: Daniella Arêas Mendes-da-Cruz and Wilson Savino, Laboratory on Thymus Research, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Ave. Brasil 4365, Manguinhos, 21045-900, Rio de Janeiro, Brazil. Voice: 55 21 38658116; fax: 55 21 22094110. daniella@ioc.fiocruz.br or savino@fiocruz.br

Abstract

Some molecules described in the nervous system are also expressed in cells involved in the control of the immune response, suggesting they have a role as common mechanisms between neuroendocrine and immune systems. In this review, we focus on the expression and role of neuropilins (NPs) and their soluble ligands class 3 semaphorins in thymus physiology, particularly migration of developing thymocytes. We also discuss the concept of multivectorial thymocyte migration, including semaphorins, as a new individual cell migration vector.

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