Neuropilins, Semaphorins, and Their Role in Thymocyte Development

  1. Daniella Arêas Mendes-da-Cruz1,2,
  2. Yves Lepelletier2,
  3. Anne C. Brignier2,
  4. Salete Smaniotto3,
  5. Amédée Renand2,
  6. Pierre Milpied2,
  7. Mireille Dardenne2,
  8. Olivier Hermine2,4,†,
  9. Wilson Savino1,†

Article first published online: 9 FEB 2009

DOI: 10.1111/j.1749-6632.2008.03980.x

Issue

Annals of the New York Academy of Sciences

Annals of the New York Academy of Sciences

Additional Information

How to Cite

Mendes-da-Cruz, D. A., Lepelletier, Y., Brignier, A. C., Smaniotto, S., Renand, A., Milpied, P., Dardenne, M., Hermine, O. and Savino, W. (2009), Neuropilins, Semaphorins, and Their Role in Thymocyte Development. Annals of the New York Academy of Sciences, 1153: 20–28. doi: 10.1111/j.1749-6632.2008.03980.x

Author Information

  1. 1

    Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil

  2. 2

    Paris Descartes University, Centre National de la Recherche Scientifique, Unité Mixte de Recherche 8147, Necker Hospital, Paris, France

  3. 3

    Institute of Biomedical and Health Sciences, Federal University of Alagoas, Maceió, Brazil

  4. 4

    Assistance Publique, Hôpitaux de Paris, Paris, France

  1. †

    These authors contributed equally to this work.

*Address for correspondence: Daniella Arêas Mendes-da-Cruz and Wilson Savino, Laboratory on Thymus Research, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Ave. Brasil 4365, Manguinhos, 21045-900, Rio de Janeiro, Brazil. Voice: 55 21 38658116; fax: 55 21 22094110. daniella@ioc.fiocruz.br or savino@fiocruz.br

  1. †

    These authors contributed equally to this work.

Publication History

  1. Issue published online: 9 FEB 2009
  2. Article first published online: 9 FEB 2009

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Keywords:

  • semaphorins;
  • neuropilins;
  • thymus;
  • thymocyte migration;
  • thymocyte development

Some molecules described in the nervous system are also expressed in cells involved in the control of the immune response, suggesting they have a role as common mechanisms between neuroendocrine and immune systems. In this review, we focus on the expression and role of neuropilins (NPs) and their soluble ligands class 3 semaphorins in thymus physiology, particularly migration of developing thymocytes. We also discuss the concept of multivectorial thymocyte migration, including semaphorins, as a new individual cell migration vector.

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