Evaluation of Relaxin's Antifibrotic Action by SELDI-TOF Mass Spectrometry-Based Profiling of Relaxin Knockout Mice, a Model of Progressive Fibrosis


Address for correspondence: Professor John D. Wade, Howard Florey Institute, University of Melbourne, Victoria 3010, Australia. Voice: +61 3 8344 7285; fax: +61 3 9348 1707. john.wade@florey.edu.au


Surface-enhanced laser desorption ionization–time-of-flight mass spectrometry was employed to identify potential biomarkers for early-onset fibrosis. These biomarkers were then used to evaluate the efficacy of relaxin to reverse or ameliorate the development of the condition.