Perivascular Multipotent Progenitor Cells in Human Organs

  1. Mihaela Crisan1,
  2. Chien-Wen Chen1,
  3. Mirko Corselli1,
  4. Gabriella Andriolo2,
  5. Lorenza Lazzari2,
  6. Bruno Péault1,3

Article first published online: 25 SEP 2009

DOI: 10.1111/j.1749-6632.2009.04967.x

Issue

Annals of the New York Academy of Sciences

Annals of the New York Academy of Sciences

Volume 1176, Hematopoietic Stem Cells VII pages 118–123, September 2009

Additional Information

How to Cite

Crisan, M., Chen, C.-W., Corselli, M., Andriolo, G., Lazzari, L. and Péault, B. (2009), Perivascular Multipotent Progenitor Cells in Human Organs. Annals of the New York Academy of Sciences, 1176: 118–123. doi: 10.1111/j.1749-6632.2009.04967.x

Author Information

  1. 1

    Stem Cell Research Center, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA

  2. 2

    Cell Factory, Department of Regenerative Medicine, Fondazione Ospedale Maggiore Policlinico, Milan, Italy

  3. 3

    McGowan Institute for Regenerative Medicine, Pittsburgh, Pennsylvania, USA

*Address for correspondence: Bruno Péault, UCLA - Orthopaedic Hospital Research Center, 615 Charles E. Young Dr. South, Los Angeles, CA 90095-7358. Voice: 310-794-1339; fax: 310-825-5409. bpeault@mednet.ucla.edu.

Publication History

  1. Issue published online: 25 SEP 2009
  2. Article first published online: 25 SEP 2009

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Keywords:

  • pericyte;
  • mesenchymal stem cell

We have identified vascular pericytes in multiple human organs on expression of CD146, NG2, PDGF-Rβ, and mesenchymal stem cell markers (CD44, CD73, CD90, CD105) and absence of blood, endothelial, and myogenic cell markers. Pericytes purified from all tissues were myogenic in culture and in vivo, sustained long-term culture during which they expressed markers of mesenchymal stem cells, and exhibited, at the clonal level, osteogenic, chondrogenic, and adipogenic potentials. These results suggest that human capillary and microvessel walls all over the organism harbor a reserve of progenitor cells that are at the origin of the elusive mesenchymal stem cells, so far identified only retrospectively in primary tissue cultures.

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