Conceptual and Methodological Biases in Network Models
Version of Record online: 15 OCT 2009
© 2009 New York Academy of Sciences.
Annals of the New York Academy of Sciences
Volume 1178, Natural Genetic Engineering and Natural Genome Editing pages 291–304, October 2009
How to Cite
Lamm, E. (2009), Conceptual and Methodological Biases in Network Models. Annals of the New York Academy of Sciences, 1178: 291–304. doi: 10.1111/j.1749-6632.2009.05009.x
- Issue online: 15 OCT 2009
- Version of Record online: 15 OCT 2009
- weak linkage;
- epigenetic inheritance;
- evolutionary transitions;
Many natural and biological phenomena can be depicted as networks. Theoretical and empirical analyses of networks have become prevalent. I discuss theoretical biases involved in the delineation of biological networks. The network perspective is shown to dissolve the distinction between regulatory architecture and regulatory state, consistent with the theoretical impossibility of distinguishing a priori between “program” and “data.” The evolutionary significance of the dynamics of trans-generational and interorganism regulatory networks is explored and implications are presented for understanding the evolution of the biological categories development-heredity, plasticity-evolvability, and epigenetic-genetic.