Structural basis of influenza virus neutralization
Article first published online: 11 JAN 2011
© 2011 New York Academy of Sciences.
Annals of the New York Academy of Sciences
Volume 1217, The Year in Immunology pages 178–190, January 2011
How to Cite
Han, T. and Marasco, W. A. (2011), Structural basis of influenza virus neutralization. Annals of the New York Academy of Sciences, 1217: 178–190. doi: 10.1111/j.1749-6632.2010.05829.x
- Issue published online: 28 JAN 2011
- Article first published online: 11 JAN 2011
- neutralizing antibodies;
Although seasonal influenza vaccines play a valuable role in reducing the spread of virus at the population level, ongoing viral evolution to evade immune responses remains problematic. No current vaccines elicit enduring protection in the face of emerging and re-emerging influenza viruses that are rapidly undergoing antigenic drift. Eliciting broadly cross-neutralizing antibody (nAb) responses against influenza virus is a crucial goal for seasonal and pandemic influenza vaccine preparation. Recent three-dimensional structure information obtained from crystallization of influenza antigens in complex with nAbs has provided a framework for interpreting antibody-based viral neutralization that should aid in the design of vaccine immunogens. Here, we will review current knowledge of the structure-based mechanisms contributing to the neutralization and neutralization escape of influenza viruses. We will also explore the potential for this structure-based approach to overcome the obstacles in developing the highly desired “universal” influenza vaccine.