Anti-inflammatory effects of resveratrol: possible role in prevention of age-related cardiovascular disease


  • Anna Csiszar

    1. University of Oklahoma Health Sciences Center, Reynolds Oklahoma Center on Aging, The Donald W. Reynolds Department of Geriatric Medicine and Department of Physiology, Oklahoma City, Oklahoma
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Address for correspondence: Anna Csiszar, M.D., Ph.D., Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma HSC, 975 N. E. 10th Street – BRC 1315, Oklahoma City, OK 73104.


Cardiovascular diseases are the most common cause of death among the elderly in the Western world. Resveratrol (3,5,4′-trihydroxystilbene) is a plant-derived polyphenol that was shown to exert diverse anti-aging activity mimicking some of the molecular and functional effects of caloric restriction. This mini-review focuses on the molecular and cellular mechanisms activated by resveratrol in the vascular system, and explores the links between its anti-oxidative and anti-inflammatory effects, which could be exploited for the prevention or amelioration of vascular aging in the elderly.