- Top of page
- Resveratrol: from plants to mammal brain-targeting
- Resveratrol and astroglial plasticity
- Hypothesis for the resveratrol on the tripartite synapse
- Conclusions and future directions
- Conflicts of interest
Resveratrol, a redox active compound present in grapes and wine, has a wide range of biological effects, including cardioprotective, chemopreventive, and anti-inflammatory activities. The central nervous system is a target of resveratrol, which can pass the blood–brain barrier and induce neuroprotective effects. Astrocytes are one of the most functionally diverse groups of cells in the nervous system, intimately associated with glutamatergic metabolism, transmission, synaptic plasticity, and neuroprotection. In this review, we focus on the resveratrol properties and response to oxidative insult on important astroglial parameters involved in brain plasticity, such as glutamate uptake, glutamine synthetase activity, glutathione content, and secretion of the trophic factor S100B.