• 1
    Patel, V.B., S. Misra, B.B. Patel & A.P. Majumdar. 2010. Colorectal cancer: chemopreventive role of curcumin and resveratrol. Nutr. Cancer. 62: 958967.
  • 2
    Gullett, N.P., A.R. Ruhul Amin, S. Bayraktar, et al . 2010. Cancer prevention with natural compounds. Semin. Oncol. 37: 258281.
  • 3
    Kraft, T.E., D. Parisotto, C. Schempp & T. Efferth. 2009. Fighting cancer with red wine? Molecular mechanisms of resveratrol. Crit. Rev. Food Sci. Nutr. 49: 782799.
  • 4
    Sadruddin, S. & R.J. Arora. 2009. Resveratrol: biologic and therapeutic implications. Cardiometab. Syndr. 4: 102106.
  • 5
    Granados-Principal, S., J.L. Quiles, C.L. Ramirez-Tortosa, et al . 2010. New advances in molecular mechanisms and the prevention of adriamycin toxicity by antioxidant nutrients. Food Chem. Toxicol. 48: 14251438.
  • 6
    Liu, E.H., L.W. Qi, Q. Wu, et al . 2009. Anticancer agents derived from natural products. Mini. Rev. Med. Chem. 9: 15471555.
  • 7
    Liu, B.L., X. Zhang, W. Zhang & H.N. Zhen. 2007. New enlightenment of French Paradox: resveratrol's potential for cancer chemoprevention and anti-cancer therapy. Cancer Biol. Ther. 6: 18331836.
  • 8
    Jang, M., L. Cai, G.O. Udeani, et al . 1997. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science 275: 218220.
  • 9
    Baur, J.A. & D.A. Sinclair. 2006. Therapeutic potential of resveratrol: the in vivo evidence. Nat. Rev. Drug Discov. 5: 493506.
  • 10
    Athar, M., J.H. Back, X. Tang, et al . 2007. Resveratrol: a review of preclinical studies for human cancer prevention. Toxicol. Appl. Pharmacol. 224: 274283.
  • 11
    Boocock, D.J., G.E. Faust, K.R. Patel, et al . 2007. Phase I dose escalation pharmacokinetic study in healthy volunteers of resveratrol, a potential cancer chemopreventive agent. Cancer Epidemiol. Biomarkers Prev. 16: 12461252.
  • 12
    Niles, R.M., C.P. Cook, G.G. Meadows, et al . 2006. Resveratrol is rapidly metabolized in athymic (nu/nu) mice and does not inhibit human melanoma xenograft tumor growth. J. Nutr. 136: 25422456.
  • 13
    Wenzel, E., T. Soldo, H. Erbersdobler & V. Somoza. 2005. Bioactivity and metabolism of trans-resveratrol orally administered to Wistar rats. Mol. Nutr. Food Res. 49: 482494.
  • 14
    Gao, X., Y.X. Xu, G. Divine, et al . 2002. Disparate in vitro and in vivo antileukemic effects of resveratrol, a natural polyphenolic compound found in grapes. J. Nutr. 132: 20762081.
  • 15
    Kimura, Y. & H. Okuda. 2001. Resveratrol isolated from Polygonum cuspidatum root prevents tumor growth and metastasis to lung and tumor-induced neovascularization in Lewis lung carcinoma-bearing mice. J. Nutr. 131: 18441849.
  • 16
    Li, Z.G., T. Hong, Y. Shimada, et al . 2002. Suppression of N-nitrosomethylbenzylamine (NMBA)-induced esophageal tumorigenesis in F344 rats by resveratrol. Carcinogenesis 23: 15311536.
  • 17
    Falschlehner, C., T.M. Ganten, R. Koschny, et al . 2009. TRAIL and other TRAIL receptor agonists as novel cancer therapeutics. Adv. Exp. Med. Biol. 647: 195206.
  • 18
    Pervaiz, S. 2001. Resveratrol: from the bottle to the bedside? Leuk. Lymphoma 40: 491498.
  • 19
    Gatouillat, G., E. Balasse, D. Joseph-Pietras, et al . 2010. Resveratrol induces cell-cycle disruption and apoptosis in chemoresistant B16 melanoma. J. Cell Biochem. [Epub ahead of print.
  • 20
    Brizuela, L., A. Dayon, N. Doumerc, et al . 2010. The sphingosine kinase-1 survival pathway is a molecular target for the tumor-suppressive tea and wine polyphenols in prostate cancer. FASEB J. [Epub ahead of print.
  • 21
    Li, H., W.K. Wu, Z. Zheng, et al . 2010. 3,3′,4,5,5′-pentahydroxy-trans-stilbene, a resveratrol derivative, induces apoptosis in colorectal carcinoma cells via oxidative stress. Eur. J. Pharmacol. 637: 5561.
  • 22
    Madan, E., S. Prasad, P. Roy, et al . 2008. Regulation of apoptosis by resveratrol through JAK/STAT and mitochondria mediated pathway in human epidermoid carcinoma A431 cells. Biochem. Biophys. Res. Commun. 377: 12321237.
  • 23
    Staudt, L.M. 2010. Oncogenic activation of NF-kappaB. Cold Spring Harb. Perspect. Biol. 2: a000109.
  • 24
    Kucharczak, J., M.J. Simmons, Y. Fan & C. Gélinas. 2003. To be, or not to be: NF-kappaB is the answer–role of Rel/NF-kappaB in the regulation of apoptosis. Oncogene. 22: 89618982.
  • 25
    Sughra, K., A. Birbach, R. de Martin & J.A. Schmid. 2010. Interaction of the TNFR-receptor associated factor TRAF1 with I-kappa B kinase-2 and TRAF2 indicates a regulatory function for NF-kappa B signaling. PLoS One 5: e12683.
  • 26
    Csaki, C., A. Mobasheri & M. Shakibaei. 2009. Synergistic chondroprotective effects of curcumin and resveratrol in human articular chondrocytes: inhibition of IL-1beta-induced NF-kappaB-mediated inflammation and apoptosis. Arthritis Res. Ther. 11: R165.
  • 27
    Roy, P., E. Madan, N. Kalra, et al . 2009. Resveratrol enhances ultraviolet B-induced cell death through nuclear factor-kappaB pathway in human epidermoid carcinoma A431 cells. Biochem. Biophys. Res. Commun. 384: 215220.
  • 28
    Benitez, D.A., M.A. Hermoso, E. Pozo-Guisado, et al . 2009. Regulation of cell survival by resveratrol involves inhibition of NF kappa B-regulated gene expression in prostate cancer cells. Prostate. 69: 10451054.
  • 29
    Yang, Y.T., C.J. Weng, C.T. Ho & G.C. Yen. 2009. Resveratrol analog-3,5,4′-trimethoxy-trans-stilbene inhibits invasion of human lung adenocarcinoma cells by suppressing the MAPK pathway and decreasing matrix metalloproteinase-2 expression. Mol. Nutr. Food Res. 53: 407416.
  • 30
    Shakibaei, M., C. Csaki, S. Nebrich & A. Mobasheri. 2008. Resveratrol suppresses interleukin-1beta-induced inflammatory signaling and apoptosis in human articular chondrocytes: potential for use as a novel nutraceutical for the treatment of osteoarthritis. Biochem. Pharmacol. 76: 14261439.
  • 31
    Harikumar, K.B. & B.B. Aggarwal. 2008. Resveratrol: a multitargeted agent for age-associated chronic diseases. Cell Cycle 7: 10201035.
  • 32
    Sun, X., Y. Zhang, J. Wang, et al . 2010. Beta-arrestin 2 modulates resveratrol-induced apoptosis and regulation of Akt/GSK3beta pathways in human endometrial cancer cells. Biochim. Biophys. Acta. [Epub ahead of print.
  • 33
    Park, E.S., Y. Lim, J.T. Hong, et al . 2010. Pterostilbene, a natural dimethylated analog of resveratrol, inhibits rat aortic vascular smooth muscle cell proliferation by blocking Akt-dependent pathway. Vascul. Pharmacol. 53: 6167.
  • 34
    Bai, Y., Q.Q. Mao, J. Qin, et al . 2010. Resveratrol induces apoptosis and cell cycle arrest of human T24 bladder cancer cells in vitro and inhibits tumor growth in vivo. Cancer Sci. 101: 488493.
  • 35
    Parekh, P., L. Motiwale, N. Naik & K.V. Rao. 2010. Downregulation of cyclin D1 is associated with decreased levels of p38 MAP kinases, Akt/PKB and Pak1 during chemopreventive effects of resveratrol in liver cancer cells. Exp. Toxicol. Pathol. [Epub ahead of print.
  • 36
    Queen, B.L. & T.O. Tollefsbol. 2010. Polyphenols and aging. Curr. Aging Sci. 3: 3442.
  • 37
    Chung, S., H. Yao, S. Caito, et al . Regulation of SIRT1 in cellular functions: role of polyphenols. Arch. Biochem. Biophys. 501: 7990.
  • 38
    de Kreutzenberg, S.V., G. Ceolotto, I. Papparella, et al . 2010. Downregulation of the longevity-associated protein sirtuin 1 in insulin resistance and metabolic syndrome: potential biochemical mechanisms. Diabetes 59: 10061015.
  • 39
    Hofseth, L.J., U.P. Singh, N.P. Singh, et al . 2010. Taming the beast within: resveratrol suppresses colitis and prevents colon cancer. Aging (Albany NY). 2: 183184.
  • 40
    Cui, X., Y. Jin, A.B. Hofseth, et al. 2010. Resveratrol suppresses colitis and colon cancer associated with colitis. Cancer Prev. Res. (Phila).;3: 54959. Epub 2010 Mar 23.
  • 41
    Arunachalam, G., H. Yao, I.K. Sundar, et al . 2010. SIRT1 regulates oxidant- and cigarette smoke-induced eNOS acetylation in endothelial cells: role of resveratrol. Biochem. Biophys. Res. Commun. 393: 6672.
  • 42
    Wang, J., Q. Wang, H. Liu, et al . 2010. MicroRNA expression and its implication for the diagnosis and therapeutic strategies of gastric cancer. Cancer Lett. 297: 137143.
  • 43
    Li, Y., D. Kong, Z. Wang & F.H. Sarkar. 2010. Regulation of microRNAs by natural agents: an emerging field in chemoprevention and chemotherapy research. Pharm. Res. 27: 10271041.
  • 44
    Marques, F.Z., M.A. Markus & B.J. Morris. 2010. The molecular basis of longevity, and clinical implications. Maturitas 65: 8791.
  • 45
    Sarkar, F.H., Y. Li, Z. Wang & D. Kong. 2009. Cellular signaling perturbation by natural products. Cell Signal. 21: 15411547.
  • 46
    Vanamala, J., L. Reddivari, S. Radhakrishnan & C. Tarver. 2010. Resveratrol suppresses IGF-1 induced human colon cancer cell proliferation and elevates apoptosis via suppression of IGF-1R/Wnt and activation of p53 signaling pathways. BMC Cancer. 10: 238.
  • 47
    Hope, C., K. Planutis, M. Planutiene, et al . 2008. Low concentrations of resveratrol inhibit Wnt signal throughput in colon-derived cells: implications for colon cancer prevention. Mol. Nutr. Food Res. 52: 5261.
  • 48
    Sakoguchi-Okada, N., F. Takahashi-Yanaga, K. Fukada, et al . 2007. Celecoxib inhibits the expression of survivin via the suppression of promoter activity in human colon cancer cells. Biochem. Pharmacol. 73: 13181329.