Adipokines as novel biomarkers and regulators of the metabolic syndrome

Authors

  • Yingfeng Deng,

    1. Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.
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  • Philipp E. Scherer

    Corresponding author
    1. Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas.
    2. Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas
      Address for correspondence: Philipp E. Scherer, Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-8549. Philipp.Scherer@utsouthwestern.edu
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Errata

This article is corrected by:

  1. Errata: Erratum for Ann. N. Y. Acad. Sci. 1212: E1–19 Volume 1226, 50, Article first published online: 26 May 2011

Address for correspondence: Philipp E. Scherer, Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-8549. Philipp.Scherer@utsouthwestern.edu

Abstract

Over the past two decades our view of adipose tissue has undergone a dramatic change from an inert energy storage tissue to an active endocrine organ. Adipose tissue communicates with other central and peripheral organs by synthesis and secretion of a host of molecules that we generally refer to as adipokines. The levels of some adipokines correlate with specific metabolic states and have the potential to impact directly upon the metabolic homeostasis of the system. A dysregulation of adipokines has been implicated in obesity, type 2 diabetes, hypertension, cardiovascular disease, and an ever-growing larger list of pathological changes in a number of organs. Here, we review the recent progress regarding the synthesis, secretion, and physiological function of adipokines with perspectives on future directions and potential therapeutic goals.

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