The role of the PD-1 pathway in autoimmunity and peripheral tolerance
Version of Record online: 28 JAN 2011
© 2011 New York Academy of Sciences.
Annals of the New York Academy of Sciences
Volume 1217, The Year in Immunology pages 45–59, January 2011
How to Cite
Fife, B. T. and Pauken, K. E. (2011), The role of the PD-1 pathway in autoimmunity and peripheral tolerance. Annals of the New York Academy of Sciences, 1217: 45–59. doi: 10.1111/j.1749-6632.2010.05919.x
- Issue online: 28 JAN 2011
- Version of Record online: 28 JAN 2011
- T cell;
Programmed death-1 (PD-1) is a surface receptor critical for the regulation of T cell function during immunity and tolerance. PD-1 interactions with its ligands PD-L1 and PD-L2 inhibit T cell effector functions in an antigen-specific manner. This paper examines the role of PD-1 in limiting autoreactivity and establishing self-tolerance and discusses the hypothesis that PD-1 ligand (PD-L) expression both spatially and temporally dictates the fate of self-reactive T cells during the breakdown of peripheral tolerance and development of autoimmunity. We focus our discussion on the role of PD-1/PD-L interactions during peripheral tolerance, the differential role for PD-L1 and PD-L2 in response to environmental or self-antigens, and the impact of PD-1 signaling on dynamic T cell motility and the T cell receptor (TCR) stop signal. Finally, we discuss the potential to selectively target the PD-1 pathway therapeutically to alter T cell function during autoimmunity.