PET/CT in diagnosis of movement disorders
Article first published online: 30 JUN 2011
© 2011 New York Academy of Sciences.
Annals of the New York Academy of Sciences
Volume 1228, PET/CT Applications in Non-neoplastic Conditions pages 93–108, June 2011
How to Cite
Berti, V., Pupi, A. and Mosconi, L. (2011), PET/CT in diagnosis of movement disorders. Annals of the New York Academy of Sciences, 1228: 93–108. doi: 10.1111/j.1749-6632.2011.06025.x
- Issue published online: 30 JUN 2011
- Article first published online: 30 JUN 2011
- movement disorders;
- Parkinson’s disease
Molecular imaging with PET offers a broad variety of tools supporting the diagnosis of movement disorders. The more widely applied PET imaging techniques have focused on the assessment of neurotransmitter systems, predominantly the pre- and postsynaptic dopaminergic system. Additionally, PET imaging with [18F]fluorodeoxyglucose has been extensively used to assess local synaptic activity in the resting state and to highlight local changes in brain metabolism accompanying changes in neural activity in movement disorders. PET imaging has provided us with diagnostic agents as well as tools for evaluation of novel therapeutics, and has served as a powerful means for revealing in vivo changes at different stages of movement disorders and within the course of an individual patient's illness.