Avian biomodels for use as pharmaceutical bioreactors and for studying human diseases
Article first published online: 27 JUL 2011
© 2011 New York Academy of Sciences.
Annals of the New York Academy of Sciences
Volume 1229, Nutrition and Physical Activity in Aging, Obesity, and Cancer pages 69–75, July 2011
How to Cite
Song, G. and Han, J. Y. (2011), Avian biomodels for use as pharmaceutical bioreactors and for studying human diseases. Annals of the New York Academy of Sciences, 1229: 69–75. doi: 10.1111/j.1749-6632.2011.06087.x
- Issue published online: 27 JUL 2011
- Article first published online: 27 JUL 2011
- germ cells;
Animal-based biotechnologies involve the use of domestic animals for the production of pharmaceuticals and various proteins in milk and eggs, as disease models, as tools for stem cell research and animal cloning, and as sources of organs for xenotransplantation into humans. Avian species offer several advantages over mammalian models, and they have been used historically to advance the fields of embryology, immunology, oncology, virology, and vaccine development. In addition, avian species can be used for studying the etiology of human ovarian cancer and other human diseases such as disorders based on the abnormal metabolism of lipids and as unique mechanisms for the biosynthesis and transport of cholesterol. This review integrates recent progress and insight into the molecular and physiologic mechanisms associated with transgenic birds and gives an overview of the use of avian models as pharmaceutical bioreactors and as tools for studying human diseases.