Obesity-induced metabolic stresses in breast and colon cancer
Article first published online: 27 JUL 2011
© 2011 New York Academy of Sciences.
Annals of the New York Academy of Sciences
Volume 1229, Nutrition and Physical Activity in Aging, Obesity, and Cancer pages 61–68, July 2011
How to Cite
Sung, M.-K., Yeon, J.-Y., Park, S.-Y., Park, J. H. Y. and Choi, M.-S. (2011), Obesity-induced metabolic stresses in breast and colon cancer. Annals of the New York Academy of Sciences, 1229: 61–68. doi: 10.1111/j.1749-6632.2011.06094.x
- Issue published online: 27 JUL 2011
- Article first published online: 27 JUL 2011
- breast cancer;
- colon cancer
Epidemiological studies have suggested that excess body weight gain may be a major risk factor for colon and breast cancer. A positive energy balance creates metabolic stresses, including the excess production of reactive oxygen species (ROS), hyperinsulinemia, the elevated adipokine secretion, and increased gut permeability. Obesity is a risk factor for breast cancer in postmenopausal women, and overweight women are more likely to have poor outcomes. The higher circulating concentration of insulin-like growth factor 1 (IGF-1) in overweight and obese women is thought to be an important mediator to promote cell proliferation and survival via the activation of phosphatidylinositol 3-kinase (PI3K)/Akt and mitogen-activated protein kinase (MAPK)/p38 signaling pathways. In an animal model of colon carcinogenesis, overweight mice fed a high-fat diet exhibited a greater number of colon tumors than lean animals. The increased abdominal fat was associated with higher concentrations of leptin, insulin, and IGF-1, which possibly mediate tumor growth. These data suggest that the metabolic burden created by excess adiposity accelerates uncontrolled cell growth and survival, thereby increasing the risk of developing breast and colon cancer.