Growth hormone–STAT5 regulation of growth, hepatocellular carcinoma, and liver metabolism
Version of Record online: 27 JUL 2011
© 2011 New York Academy of Sciences.
Annals of the New York Academy of Sciences
Volume 1229, Nutrition and Physical Activity in Aging, Obesity, and Cancer pages 29–37, July 2011
How to Cite
Baik, M., Yu, J. H. and Hennighausen, L. (2011), Growth hormone–STAT5 regulation of growth, hepatocellular carcinoma, and liver metabolism. Annals of the New York Academy of Sciences, 1229: 29–37. doi: 10.1111/j.1749-6632.2011.06100.x
- Issue online: 27 JUL 2011
- Version of Record online: 27 JUL 2011
- growth hormone;
- liver function
The liver is a primary target of growth hormone (GH). GH signals are mediated by the transcription factor signal transducer and activator of transcription 5 (STAT5). Here, we focus on recent discoveries about the role of GH–STAT5 signaling in hepatic physiology and pathophysiology. We discuss roles of the GH–STAT5 axis in body growth, lipid metabolism, and the cell cycle pertaining to hepatosteatosis, fibrosis, and hepatocellular carcinoma. Finally, we discuss recent discoveries about the role of GH–STAT5 in sex-specific gene expression and bile acid, steroid, and drug metabolism.