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Keywords:

  • growth hormone;
  • STAT5;
  • liver function

The liver is a primary target of growth hormone (GH). GH signals are mediated by the transcription factor signal transducer and activator of transcription 5 (STAT5). Here, we focus on recent discoveries about the role of GH–STAT5 signaling in hepatic physiology and pathophysiology. We discuss roles of the GH–STAT5 axis in body growth, lipid metabolism, and the cell cycle pertaining to hepatosteatosis, fibrosis, and hepatocellular carcinoma. Finally, we discuss recent discoveries about the role of GH–STAT5 in sex-specific gene expression and bile acid, steroid, and drug metabolism.