Myricetin is a potent chemopreventive phytochemical in skin carcinogenesis

Authors

  • Nam Joo Kang,

    1. School of Food Science and Biotechnology, Kyungpook National University, Daegu, Republic of Korea.
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  • Sung Keun Jung,

    1. Hormel Institute, University of Minnesota, Austin, Minnesota, USA.
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  • Ki Won Lee,

    1. Food Science and Biotechnology Program, Department of Agricultural Biotechnology
    2. Center for Agricultural Biomaterials, Seoul National University, Seoul, Republic of Korea.
    3. Advanced Institutes of Convergence Technology, Suwon-si, Gyeonggi-do, Republic of Korea
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  • Hyong Joo Lee

    1. WCU Biomodulation Program, Department of Agricultural Biotechnology
    2. Center for Agricultural Biomaterials, Seoul National University, Seoul, Republic of Korea.
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Hyong Joo Lee, Department of Agricultural Biotechnology, Seoul National University, Seoul 151-921, Republic of Korea. leehyjo@snu.ac.kr; Ki Won Lee, Department of Agricultural Biotechnology, Seoul National University, Seoul 151–921, Republic of Korea, kiwon@snu.ac.kr

Abstract

Myricetin is a widely distributed flavonol that is found in many plants, including tea, berries, fruits, vegetables, and medicinal herbs. Abundant sources provide interesting insights into the multiple mechanisms by which myricetin mediates chemopreventive effects on skin cancer. Myricetin strongly inhibited tumor promoter–induced neoplastic cell transformation by inhibiting MEK, JAK1, Akt, and MKK4 kinase activity directly. In a mouse skin model, myricetin attenuated the ultraviolet B (UVB)–induced COX-2 expression and skin tumor formation by regulating Fyn. Myricetin-mediated inactivation of Akt in the UVB response plays a role in regulating UVB-induced carcinogenesis. Recently, myricetin was found to inhibit UVB-induced angiogenesis by targeting PI3-K in an SKH-1 hairless mouse skin tumorigenesis model. Raf kinase is a critical target for myricetin in inhibiting the UVB-induced formation of wrinkles and suppression of type I procollagen and collagen levels in mouse skin. Accumulated data suggest that myricetin acts as a promising agent for the chemoprevention of skin cancer.

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