Noninvasive imaging of bone microarchitecture
Article first published online: 15 DEC 2011
© 2011 New York Academy of Sciences.
Annals of the New York Academy of Sciences
Volume 1240, Skeletal Biology and Medicine II: Bone and cartilage homeostasis and bone disease pages 77–87, December 2011
How to Cite
Patsch, J. M., Burghardt, A. J., Kazakia, G. and Majumdar, S. (2011), Noninvasive imaging of bone microarchitecture. Annals of the New York Academy of Sciences, 1240: 77–87. doi: 10.1111/j.1749-6632.2011.06282.x
- Issue published online: 15 DEC 2011
- Article first published online: 15 DEC 2011
- high-resolution peripheral quantitative computed tomography (HR-pQCT);
- high-resolution magnetic resonance imaging (HR-MRI);
- bone microarchitecture;
- bone quality
The noninvasive quantification of peripheral compartment-specific bone microarchitecture is feasible with high-resolution peripheral quantitative computed tomography (HR-pQCT) and high-resolution magnetic resonance imaging (HR-MRI). In addition to classic morphometric indices, both techniques provide a suitable basis for virtual biomechanical testing using finite element (FE) analyses. Methodical limitations, morphometric parameter definition, and motion artifacts have to be considered to achieve optimal data interpretation from imaging studies. With increasing availability of in vivo high-resolution bone imaging techniques, special emphasis should be put on quality control including multicenter, cross-site validations. Importantly, conclusions from interventional studies investigating the effects of antiosteoporotic drugs on bone microarchitecture should be drawn with care, ideally involving imaging scientists, translational researchers, and clinicians.