Development and function of interleukin 17–producing γδ T cells
Article first published online: 12 JAN 2012
© 2012 New York Academy of Sciences.
Annals of the New York Academy of Sciences
Volume 1247, The Year in Immunology pages 34–45, January 2012
How to Cite
Korn, T. and Petermann, F. (2012), Development and function of interleukin 17–producing γδ T cells. Annals of the New York Academy of Sciences, 1247: 34–45. doi: 10.1111/j.1749-6632.2011.06355.x
- Issue published online: 31 JAN 2012
- Article first published online: 12 JAN 2012
- γδ T cells;
- T cell lineage;
- experimental autoimmune encephalomyelitis
Interleukin (IL) 17 is a phylogenetically ancient cytokine that has been adopted by the adaptive immune system, and the investigation of adaptive T helper (Th) 17 cells has substantially contributed to our understanding of the molecular requirements for the induction, regulation, and function of IL-17. However, IL-17 is in fact produced by a large variety of innate immune cells and exerts its most significant biological functions at the interface of the organism with its environment, such as, for example, at epithelial surfaces, where γδ T cells are a prominent source of IL-17. In this review, we will give an overview on the concepts of commitment of γδ T cells to effector phenotypes, focusing on IL-17–producing γδ T cells (γδT17 cells). The role of γδT17 cells in animal models of autoimmunity will be discussed as well as the prerequisites for the development of human γδT17 cells and their potential importance for human disease conditions.