Common variable immunodeficiency (CVID): exploring the multiple dimensions of a heterogeneous disease
Article first published online: 2 FEB 2012
© 2012 New York Academy of Sciences.
Annals of the New York Academy of Sciences
Volume 1250, The Year in Human and Medical Genetics: Inborn Errors of Immunity III pages 41–49, February 2012
How to Cite
Salzer, U., Unger, S. and Warnatz, K. (2012), Common variable immunodeficiency (CVID): exploring the multiple dimensions of a heterogeneous disease. Annals of the New York Academy of Sciences, 1250: 41–49. doi: 10.1111/j.1749-6632.2011.06377.x
- Issue published online: 24 FEB 2012
- Article first published online: 2 FEB 2012
- primary immunodeficiency;
- B cells;
Common variable immunodeficiency (CVID) represents a large heterogeneous group of antibody deficiency syndromes associated with a plethora of clinical features and as yet largely undefined molecular causes. We are now seeing this heterogeneous group being increasingly defined into single-gene and polygenic disorders after stratification into homogeneous patient subgroups based on improved clinical and immunological criteria, including molecular, functional, immunohistological, and longitudinal and outcome information. In this perspective, we highlight recent developments in CVID, addressing mainly its genetic and immunological dimensions.