Perspectives on tight junction research
Article first published online: 6 JUN 2012
© 2012 New York Academy of Sciences.
Annals of the New York Academy of Sciences
Volume 1257, Barriers and Channels Formed by Tight Junction Proteins I pages 1–19, June 2012
How to Cite
Schulzke, J.-D., Günzel, D., John, L. J. and Fromm, M. (2012), Perspectives on tight junction research. Annals of the New York Academy of Sciences, 1257: 1–19. doi: 10.1111/j.1749-6632.2012.06485.x
- Issue published online: 6 JUN 2012
- Article first published online: 6 JUN 2012
- paracellular channel;
- inflammatory bowel disease
The tight junction connects neighboring epithelial or endothelial cells. As a general function, it seals the paracellular pathway and thus prevents back-leakage of just transported solutes and water. However, not all tight junctions are merely tight: some tight junction proteins build their own transport pathways by forming channels selective for small cations, anions, or water. Two families of tight junction proteins have been identified, claudins (27 members in mammals) and tight junction-associated MARVEL proteins ((TAMPs) occludin, tricellulin, and MarvelD3); an additional, structurally different, junction protein is junction adhesion molecule (JAM). Besides classification by genetic or molecular kinship, classification of tight junction proteins has been suggested according to permeability attributes. Recent studies describe specific cis and trans interactions and manifold physiologic regulations of claudins and TAMPs. In many inflammatory and infectious diseases they are found to be altered, for example, causing adversely increased permeability. Currently, attempts are being made to alter the paracellular barrier for therapeutic interventions or for transiently facilitating drug uptake. This overview concludes with a list of open questions and future topics in tight junction research.