The link between altered cholesterol metabolism and Alzheimer's disease
Article first published online: 3 JUL 2012
© 2012 New York Academy of Sciences.
Annals of the New York Academy of Sciences
Volume 1259, Environmental Stressors in Biology and Medicine pages 54–64, July 2012
How to Cite
Gamba, P., Testa, G., Sottero, B., Gargiulo, S., Poli, G. and Leonarduzzi, G. (2012), The link between altered cholesterol metabolism and Alzheimer's disease. Annals of the New York Academy of Sciences, 1259: 54–64. doi: 10.1111/j.1749-6632.2012.06513.x
- Issue published online: 3 JUL 2012
- Article first published online: 3 JUL 2012
- Alzheimer's disease;
- oxidative stress;
Alzheimer's disease (AD), the most common form of dementia, is characterized by the progressive loss of neurons and synapses, and by extracellular deposits of amyloid-β (Aβ) as senile plaques, Aβ deposits in the cerebral blood vessels, and intracellular inclusions of hyperphosphorylated tau in the form of neurofibrillary tangles. Several mechanisms contribute to AD development and progression, and increasing epidemiological and molecular evidence suggests a key role of cholesterol in its initiation and progression. Altered cholesterol metabolism and hypercholesterolemia appear to play fundamental roles in amyloid plaque formation and tau hyperphosphorylation. Over the last decade, growing evidence supports the idea that cholesterol oxidation products, known as oxysterols, may be the missing link between altered brain cholesterol metabolism and AD pathogenesis, as their involvement in neurotoxicity, mainly by interacting with Aβ peptides, is reported.